Our company offers comprehensive thermal analysis services to assist drug developers in determining the optimal formulation process for a drug, developing appropriate storage conditions, predicting drug breakdown and degradation, and assessing drug quality and stability. If you have any needs, please contact us.
Our Services
Thermal analysis refers to the study of basic physicochemical properties of APIs and excipients, such as melting point, the heat of fusion, or glass transition temperature, by thermal methods. Our company's analytical laboratory is equipped with advanced thermal analysis instruments, and our analysts have extensive work experience in the field of preformulation analysis. We can assist drug developers evaluate the thermal properties of APIs and excipients through DSC (differential scanning calorimetry), TGA (thermogravimetric analysis) and thermal expansion analysis (TMA), and understanding their properties at different temperatures and conditions, providing valuable information for drug development, preformulation, and quality control.
Differential scanning calorimetry (DSC)
DSC is a common thermal analysis technique used to measure the difference in heat between a sample and a reference. For APIs and excipients in pre-formulations, DSC can detect all physical processes that occur during heating and cooling, such as melting point, melting peak, phase transition, decomposition temperature, etc.
Thermogravimetric analysis (TGA)
TGA is a technique that measures the change in mass of a material as it heats up. In the thermal analysis of APIs and excipients in preformulations, TGA can be used to detect the thermal decomposition temperature and water loss of drugs. This is important for assessing the thermal stability of drugs and predicting drug degradation during processing and storage.
Thermal expansion analysis (TMA)
TMA measures the change in volume of a material as it is heated. For APIs and excipients in preformulations, TMA can determine their expansion properties at different temperatures, and predict the possible volume changes and changes in physical properties of the drug during the formulation process.
Advantages
- Small sample size required
- Highly accurate measurement of phase change and heat capacity
- Very precise temperature control
- Sensitive measurement of subtle or weak phase transitions
- Ability to separate overlapping thermal transitions
- Qualitative or quantitative analysis
Please kindly note that our services are for research use only.
