Preformulation Studies
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Preformulation Studies

Preformulation is an important stage in the drug development process that involves extensive physicochemical characterization of APIs prior to the development of drug dosage forms. Our company has extensive experience in the field of preformulation analysis, and our preformulation services utilize a range of cutting-edge analytical techniques, such as X-ray powder diffraction (XRPD), carbon nuclear magnetic resonance (NMR), high-performance liquid chromatography (HPLC) to help you find the optimal dosage form for your APIs. If you have any needs, please feel free to contact us.

Preformulation Studies

Our Services

Hygroscopicity Evaluation
Hygroscopicity evaluation is the process of evaluating the hygroscopic performance of APIs and excipients under different humidity conditions. Our company can determine the hygroscopicity of APIs and excipients in different humidity environments through experiments, and help customers determine the formulation of preparations, storage conditions of drugs, etc.
Thermal Analysis
Thermal analysis is the study of the properties and stability of substances by measuring their thermal properties at different temperatures. Our company can use thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC), and other techniques to test the thermal properties of APIs to determine important information such as thermal decomposition characteristics and thermal stability.
Solubility Detection
The solubility of a drug is an important factor affecting its absorption and bioavailability. Our company can evaluate the solubility and dissolution rate of APIs through in vitro test methods to support drug formulation.
Determination of Partition Coefficients
The partition coefficient describes the degree of APIs distribution in different phases (usually the oil phase and water phase), which has an important impact on drug distribution and metabolism in the body. Our company can help customers understand the in vivo behavior of APIs by determining the partition coefficient with appropriate methods.
Determination of pKa
The pKa value of APIs is an important parameter to describe its dissociation properties under different pH conditions. Our company can choose an appropriate method to determine the pKa value according to the properties of APIs and provide data support for pharmaceutical formulations.
API-Excipient Compatibility
During formulation development, drug-excipient interactions may affect its stability and efficacy. Our company can evaluate the compatibility between raw materials and excipients through various testing methods to help customers choose suitable formulations.
Particle Size Distribution
Particle size distribution refers to the percentage or number of different particle sizes present in a sample. This is critical for drug bioavailability, potency, stability, and uniformity during formulation. Our company can measure and analyze the particle size distribution of drugs in preformulation through modern particle size analysis technology, helping customers understand the size range and distribution of particles in formulation.
Particle Size Reduction
During the formulation process, the particle size of the drug may need to be adjusted to meet specific formulation requirements or to improve the bioavailability of the drug. Our company can develop appropriate methods and processes to reduce the particle size according to the customer's needs and the characteristics of the formulation.

Our Technology

Ultraviolet (UV) spectroscopyHigh-performance liquid chromatography (HPLC)
Differential scanning calorimetry (DSC)Dynamic vapor sorption (DVS)
X-ray powder diffraction (XRPD)Thin-layer chromatography (TLC)
Thermogravimetric analysis (TGA)Microscopy analysis
Dynamic light scattering (DLS)Others

Our Advantages

  • Comprehensive services: Our company offers comprehensive preformulation analytical services covering key aspects of pharmaceutical formulation development, from hygroscopicity assessment to particle size reduction.
  • Advanced technology: Our company has a series of advanced technologies, such as UV Spectroscopy, Differential Scanning Calorimetry (DSC), etc. This allows us to adapt the analytical method to the specific needs of different APIs and formulations.

Please kindly note that our services are for research use only.

Get in Touch

We’re glad to help you with your products and services demands. For any inquiry, question or recommendation, please send an email to inquiry@alfa-chemistry.com or fill out the following form.

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