Taste Masking Technology Platform

Coating Technology

This method involves applying a taste-masking coating around the drug particles. The coating acts as a barrier, preventing the drug from interacting with the taste buds while allowing it to dissolve and absorb in the gastrointestinal tract. We utilize various coating materials such as polymers and lipids, which are selected based on their compatibility with the drug and the desired release profile.

Microencapsulation

Microencapsulation involves encasing the drug particles in a micro-scale capsule, using materials that prevent the drug from dissolving in the mouth. This technology is particularly useful for liquid formulations and suspensions, providing a significant improvement in taste without impacting the drug's bioavailability.

Ion Exchange Resins

Ion exchange resins are employed to form complexes with the drug molecules. These complexes are insoluble at the pH level of the mouth but release the active drug at the pH level of the stomach or intestine. This method is especially effective for bitter-tasting drugs that need to be masked in liquid formulations.

Prodrugs

A prodrug approach involves chemically modifying the drug to an inactive form that lacks an unpleasant taste. Once ingested, the prodrug metabolizes into the active drug form in the body. This method ensures that the taste masking does not interfere with the drug's therapeutic action.

Inclusion Complexation

The inclusion complex method is typically employed when a low dose of a drug is needed. This technique involves the binding of a host and guest, with the host acting as the complexing agent and the guest as the active component. The primary function of the complexing agent is to mask the unpleasant taste of the drug by either decreasing its solubility in the mouth or reducing the drug particles that come into contact with taste receptors. At our platform, cyclodextrins are extensively used in this strategy for taste-masking bitter drugs due to its sweet in taste and non-toxic.