Chiral Catalysis Technology Platform

In the pharmaceutical industry, the significance of chirality cannot be overstated. A molecule's chirality (its geometric orientation) can profoundly influence its medicinal benefits and side effects. Often only one enantiomer is therapeutically effective. In some cases, the other enantiomer can cause adverse effects. Therefore, producing drugs with a high degree of chiral purity is essential. Chiral catalysis technology provides a method for producing enantiomerically pure compounds. The chiral catalysis are designed to preferentially induce the formation of one enantiomer over another, ensuring the production of high-purity, single-enantiomerdrugs, which are crucial in the development of safe and effective pharmaceuticals. At our company, we have built a comprehensive chiral catalysis technology platform. By harnessing cutting-edge methodologies and state-of-the-art equipment, we assist pharmaceutical companies in seamlessly integrating chiral catalysis into their drug development processes. Our focus is on creating catalysts that drive reactions towards the desired enantiomer, improving the efficiency and predictability of drug synthesis.

Access Chiral Catalysis Technology Platform

Our chiral catalysis technology platform has a comprehensive suite of capabilities designed to address the needs of in the realm of chiral drug development. These capabilities include:

Design, Synthesis, and Process Development of Chiral Ligands and Catalysts

Our platform specializes in the bespoke design and synthesis of chiral ligands and catalysts by leveraging advanced molecular modeling and synthetic chemistry techniques. Furthermore, we invest significant efforts in the process development of these molecules, ensuring they can be scaled from bench to production seamlessly.

Screening of Chiral Ligands and Catalysts

Our platform employs high-throughput screening (HTS) technologies to rapidly evaluate numerous candidates under varying conditions, allowing us to ascertain the optimal chiral catalyst for specific asymmetric transformations, significantly reducing the time needed for method development.

Application of Asymmetric Catalysis in Chiral Drug Development

Our platform specializes in the application of asymmetric catalysis in chiral drug development and has a proven track record of successfully implementing asymmetric catalytic methods in the synthesis of chiral drugs.

Synthesis and Process Development for Chiral Drugs and Intermediates

Our platform excels in the synthesis of chiral drugs and their intermediates, offering end-to-end solutions, from initial feasibility studies and route scouting to process development and optimization. By integrating asymmetric catalytic methods, we can ensure that the synthetic routes are highly enantioselective and operationally simple.

Research on Asymmetric Reactions and Their Mechanisms

Fundamental research into the mechanisms of asymmetric reactions is a cornerstone of our platform. Understanding the intricate details of these processes enables us to design more efficient catalysts and streamline reaction pathways.

To date, our platform has successfully developed scalable synthesis processes for over a hundred different chiral ligands and catalysts. Additionally, our asymmetric catalysis technology has been applied to the production of numerous chiral drugs, creating of several new pharmaceutical entities.

Instruments and Equipment at Our Platform

Our ability to deliver on these chiral catalysis services hinges on a suite of advanced instruments and equipment. Key instruments include:

High-pressure reactors
Automated parallel reaction stations
Glove boxes
High-performance liquid chromatography (HPLC) systems
Nuclear magnetic resonance (NMR) spectrometers
Mass spectrometers
...

Our chiral catalysis technology platform stands as a partner of innovation and reliability in the pharmaceutical industry. By offering cutting-edge capabilities and equipped with advanced instruments, we provide essential support to pharmaceutical companies in the development of safe, effective, and high-purity chiral drugs.

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Please kindly note that our services are for research use only.