The aim of API synthesis process optimization is to improve quality, increase yield and provide conditions for large-scale production. Our company has a team with rich experience in API route design and synthesis process optimization, and we can provide you with a one-stop service for API synthesis process optimization to help you produce high-quality, low-cost APIs. If you are troubled by the imperfect synthesis route of API, please feel free to contact us.
API Synthesis Process Optimization
The initial synthesis route and reaction conditions of API are obtained from literature and patents. When applied to large-scale production, there are often a series of problems, such as low yields of unit reactions and high levels of impurities. Therefore, it is necessary to rationally optimize the synthetic route of API to increase the yield, reduce the cost and make the production process more friendly to the environment. API synthesis process optimization is an improvement and innovation based on the existing API synthesis process, including a series of screening of optimal process conditions (parameters, solvents, additions, etc.), optimization of post-processing methods, and overall innovation of the process.
The Goal of API Synthesis Process Optimization
- Improve quality: including increasing content, reducing impurities, improving appearance and color, improving fluidity, increasing shelf life, etc.
- Reducing costs: including increasing the yield, replacing raw materials, shortening the reaction cycle, recycling solvents, etc.
- Improving large-scale production capacity: optimization of production capacity under the existing production process conditions, including batch adjustment, fine-tuning of large-scale process parameters, etc.
- Reduction of waste discharge: optimized treatment of the three wastes (gas, liquid and solid), including the absorption of waste gas, the recovery of waste liquid, and the utilization of waste residue.
Strategies for API Synthesis Process Optimization
- Small test stage: optimize the route, ensure the quality and the supply.
- Pilot test stage: the equipment is more expensive and needs to be optimized into a reasonable and stable process. The cost of raw materials may be relatively high and needs to be optimized to achieve the expected output. Low yield and low output may affect the production plan of APIs and the reaction conditions need to be optimized.
- Optimization of the production stage: the optimization of process details should not make major changes to routes, parameters, and methods.
The following are the factors that need to be considered in the optimization of API synthesis process.
| Routing | Choice of chemical reaction type |
| Synthetic steps and overall yield |
| Replacement of raw and auxiliary materials and change of synthesis steps |
| Sequence of unit reactions and evaluation |
| Technical conditions and equipment requirements |
| Process factors | Reactant concentration and ingredient ratio |
| Reaction temperature and pressure |
| Catalysts |
| Stirring |
| Reaction time and reaction end point control |
| Quality control of raw materials and intermediates |
Our Advantages
- According to the needs of customers, we can provide you with personalized services.
- Fast project completion with high success rate.
- Experienced operators, cost-effective.
Delivery
| Physicochemical properties of API | Optimization scheme of API synthesis process |
| Optimal process conditions (parameters, solvents, etc.) | Other experimental data |
Please kindly note that our services are for research use only.
