Our company is a leading supplier of APIs and pharmaceutical intermediates. We have extensive knowledge and experience in discovering co-crystals and can screen through a variety of methods to identify potential co-crystals to improve the physical and chemical properties of drugs. If you have any needs, please feel free to contact us, we will provide you with a one-stop API co-crystal screening service.
Our Service
A co-crystal is a crystalline substance in which API molecules and ligand molecules are embedded in the same lattice. For crystalline drugs, the introduction of co-crystals can be used to improve the physical and chemical properties of the drug by modulating the interactions between the different components. When the API is not easy to ionize, the addition of a ligand to form a co-crystal is preferred to improve the solubility, stability and purity of the API.
There are many techniques for drug co-crystal screening, commonly used are high-throughput crystallization screening technology, supercritical fluid enhanced spray technology, solution method, grinding method, etc. In addition, there are screening methods based on the Cambridge Crystal Structure Database, thermodynamic methods (hot stage microscopic screening, differential scanning calorimetry), and suspension crystallization screening methods. Our company can choose the right screening method for you according to your needs.
Co-Crystal Screening
APIs may have one or more unknown crystal forms. When designing the scheme, it is necessary to combine the characteristics of the APIs, select the corresponding technology (such as chemical recrystallization method, fast solvent removal method) to screen all possible crystal forms, and combine different compounds to cultivate as much as possible crystal forms. Our company provides systematic co-crystal screening studies to discover and select API co-crystals with optimal solid-state properties, including:
| Rapid screening of API co-crystals (solvates) | API co-crystal preparation |
| Optimization of co-crystals solvent | Characterization of API co-crystals |
| Develop a reliable manufacturing process | Scale-up of optimal co-crystals |
Workflow for API Co-Crystal Screening
Our Techniques
| API co-crystal preparation | Solution method: solution volatilization method, reaction crystallization method and cooling crystallization method |
| Grinding method: dry grinding, wet grinding |
| Other methods: gel method, hot-melt extrusion method, spray drying method, thermal microscopy method, super boundary fluid method, etc. |
| Screening of API co-crystals | High-throughput crystallization screening technology |
| Supercritical Fluid Enhanced Spray Technology |
| Solution method |
| Grinding method |
| Suspension crystal screening method |
| A screening method based on the Cambridge Crystal Structure Database |
| Thermodynamic methods: hot stage micro-screening, differential scanning calorimetry |
| API co-crystal characterization | PXRD powder diffraction technique |
| TGA thermogravimetric analyzer |
| DSC differential scanning calorimetry |
| Gas chromatography |
| Infrared spectroscopy |
| Raman spectroscopy |
| NMR spectroscopy |
| Scanning electron microscope method |
Our Advantages
- Our scientists have performed hundreds of co-crystal screenings and have extensive project experience.
- Using various analytical methods such as PXRD powder diffraction, GC and NMR, making APIs co-crystal can be quickly characterized.
- We have advanced co-crystal screening laboratories and equipment.
- We have an industry-leading and proven proprietary screening technology and are constantly updating and improving our screening technology.
- We have a large database of co-crystals that are pharmaceutically acceptable.
Delivery
| Optimal API co-crystal | Detailed API co-crystal screening process |
| Physicochemical properties of API co-crystal | Other experimental data |
Please kindly note that our services are for research use only.
