Our company is dedicated to delivering top-notch API structure elucidation services for pharmaceutical companies. Our services cover proteins, peptides, oligonucleotides, PEGylated proteins, small molecule APIs, antibody-drug conjugates (ADCs), and various polymers. If you have any needs, please contact us in time.
Our Services
API molecular structure elucidation is an essential part of the drug development process to ensure that the structure and properties of the API meet expectations. At our company, our team of highly skilled pharmaceutical analysis experts can utilize a range of technical to analyze the API structure. With our expertise, we can accurately analyze the structure of the following molecule:
| Structural elucidation of proteins | Structural elucidation of peptides |
| Structural elucidation of oligonucleotides | Structural elucidation of small molecule API |
| Structural elucidation of antibody-drug conjugates | Structural elucidation of other API |
Our Techniques
Nuclear Magnetic Resonance (NMR)
NMR spectrum can provide information about different cores in molecules, such as hydrogen nuclei (1H NMR), carbon nuclei (13C NMR), etc. By analyzing the position, intensity, and shape of the peaks, it is possible to determine how the atoms in the molecule are connected to each other.
Infrared Spectroscopy (IR)
IR spectroscopy can reveal the functional groups in a molecule and the bonds between them. Different chemical bonds and groups exhibit peaks at specific wavenumber ranges, which help determine the structure of the molecule.
Mass Spectrometry
MS can provide information on the molecular weight of a molecule and its fragmented fragments. By analyzing the mass spectrum, the relative arrangement of atoms in the molecule can be obtained, especially useful in complex organic molecules. Ultra-high resolution mass spectrometer for precise identification of very small amounts of proteins, peptides, oligonucleotides, PEGylated proteins and small molecule drugs, ADCs, and other polymers.
X-ray Crystallography
X-ray crystallography is a method of determining the structure of molecules by analyzing the arrangement of atoms in a crystal. This method is commonly used for structure confirmation of organic compounds, proteins, and inorganics.
Raman Spectroscopy
Raman spectroscopy can provide vibration information of chemical bonds in molecules and help determine the structure of molecules.
Proton Nuclear Magnetic Resonance Spectroscopy (HMBC)
HMBC is an NMR technique that can be used to confirm bond connections in molecules, especially long-range bonds.
Proton Assignment Spectroscopy (HSQC)
HSQC is an NMR technique that determines the correlation between hydrogen and carbon, aiding in the structural conformation of molecules.
Proton Overlap Spectrum (NOESY)
NOESY can provide nuclear magnetic coupling information in molecules and help determine the relative positions between atoms.
Other Techniques
Ultraviolet-visible spectroscopy (UV-Vis), electron spin resonance spectroscopy (ESR), fluorescence spectroscopy, etc., can also assist in the confirmation of molecular structures.
Our Advantages
- Professional team: Our company has a team of experienced scientists and experts with profound chemical and analytical backgrounds, capable of accurately interpreting complex API structures.
- Advanced equipment: The company is equipped with the most advanced analytical equipment, including high-resolution mass spectrometers, high-performance nuclear magnetic resonance instruments, and X-ray crystallographic instruments, to ensure the reliability and accuracy of the analysis results.
- Comprehensive analysis: Our company can use a variety of analytical techniques for comprehensive analysis to confirm the structure of API from different angles and reduce errors and uncertainties.
Delivery
| Mass spectrometry analysis data | NMR analysis data |
| X-ray crystallographic analysis data | Other experimental data |
Please kindly note that our services are for research use only.
