At our company, we use a range of state-of-the-art techniques to accurately determine particle size distribution. These methods include microscopy, sieving, and light scattering methods. By combining these approaches, we obtain a comprehensive understanding of the distribution of APIs and help our customers make informed decisions during the formulation stage. If you have any needs, please feel free to contact us.
Our Services
The particle size distribution of active pharmaceutical ingredients (APIs) is a critical parameter with far-reaching implications for drug development. Notably, it profoundly influences the homogeneity of preparation processes, dosage accuracy, and compressibility. More importantly, particle size distribution affects essential characteristics like solubility, duration of action, site of action, stability, and overall safety of drug formulations. Therefore, precise control of particle size plays a pivotal role in formulation development.
When it comes to ensuring the highest standards in particle size distribution analysis, our company stands as a pioneer in the pharmaceutical industry. With a wealth of experience and cutting-edge technology at our disposal, we offer comprehensive particle size distribution services specifically tailored for preformulation studies.
Our Methods
| Methods | Principle | Advantages |
|---|
| Microscope method | The image of the magnified particles is transferred to a computer, which counts the number of particles in the set size interval, and then the particle size distribution can be obtained. | It is simple and convenient, and can judge the degree of dispersion of the particles, as well as whether there is an agglomeration phenomenon. |
| Sieving method | Calculation of the weight ratio of sieved particles to the total number of particles by means of external forces (e.g. manual, mechanical, air injection) that cause the particles to vibrate, rotate, etc. | It is economical, simple, and can realize rapid determination of particle size distribution. |
| Light scattering method | Scattering occurs when the monochromatic light beam irradiates the particles to be tested. Since the energy distribution of scattered light is related to the size of particles, the particle size distribution of particles can be calculated by measuring the energy distribution of scattered light (scattering angle) according to Mie scattering theory and Fraunhofer approximation theory. | It can be used to determine the particle size distribution of APIs. The measurement range is up to 0.02~350 μm.
A laser scatterometer is a precision instrument with high accuracy and resolution, suitable for quality control. |
Advantages
- Expertise: Backed by many years of industry experience, our company boasts a team of seasoned experts who bring in-depth knowledge and insights to particle size distribution.
- Customized approach: Recognizing that particle size analysis is not a one-size-fits-all process, our company's experts meticulously customize their methods to the specifics of each sample. This tailored approach ensures accuracy and relevance, enabling our customers to make precise decisions that drive successful drug development.
Delivery
Complete experimental data are provided.
Please kindly note that our services are for research use only.
