Our company's researchers have expertise in API particle size control, and we can provide you with API particle size reduction services using grinding, micronization, and other techniques. If you have any needs, please contact us.
Our Services
In the process of drug development, most of the promising new molecules with biological activity are rejected due to low water solubility, and water solubility is closely related to the bioavailability and release of drugs. The solubility of the API can be improved by reducing the particle size. In addition, reducing the particle size of the API also significantly affects powder flowability, bulk density, hygroscopicity, compatibility, porosity, and blend uniformity. These parameters affect every stage of drug formulation, thereby influencing the effectiveness and shelf-life of the final drug dosage form. Therefore, reducing the particle size of the API is crucial in drug development.
By controlling and reducing particle size, the overall performance of active pharmaceutical ingredients (APIs) can be maximized. At our company, we offer a wide range of methods to manipulate particle size and distribution, such as controlling crystallization, micronization, grinding, and spray drying. With our advanced equipment and extensive expertise, we are capable of delivering top-notch particle size reduction services to support the entire development process of potential drug candidates. Whether you need to optimize drug formulation, enhance bioavailability, improve dissolution rate, or ensure uniformity, our team of experts can provide personalized service to meet your specific requirements.
Our Methods
Crystallization
Real-time particle size control using focused beam reflectance measurement (FBRM) together with in situ attenuated total reflection Fourier transform infrared spectroscopy (ATR FT-IR) is very useful in monitoring and controlling the particle size of API during crystallization.
Micronization
Micronization is one of the most commonly used methods to reduce particle size, which can decrease the particle size of an API to the micrometer level, significantly increasing the surface area of the substance. This method is suitable for thermosensitive products as the temperature is relatively constant throughout the process. The reduction in particle size is ultimately a result of particle collisions in the micronization chamber. Setting the micronization parameters correctly allows for the desired reduction in particle size to be achieved.
Spray Drying
Spray drying is a powerful particle engineering tool, in which different spray drying process parameters can be adjusted to control the size, shape, and density of the obtained particles. Spray drying can be used to generate spherical particles of amorphous or crystalline agglomerates, typically within the size range of 1-200 μm, depending on the experimental parameters used.
Other Methods
Grinding and vibratory sieving are also commonly used techniques in API powder processing. Grinding is mainly used for slight particle size reduction (above 10 microns). Vibrating screens are particularly useful where a specific fraction is expected to have a narrow particle size distribution.
Our Advantages
- Various methods are available: Our company offers various methods to control and modify particle size, this allows us to tailor particle properties according to your requirements.
- State-of-the-art equipment: Our company has state-of-the-art equipment for particle size reduction. This enables precise manipulation of particle size and distribution.
- Expert knowledge: Our company's team possesses extensive expertise in particle engineering and solid-state characterization. So we can provide you with optimal process parameters for particle size reduction.
Delivery
| Particle shape | Particle size uniformity |
| Average particle size | Particle size distribution curve |
| Process parameters for API particle size reduction | Other experimental data |
Please kindly note that our services are for research use only.
