Cytarabine

Cat. No.: PI147944

Description: Cytarabine (also known as cytarabine arabinoside or ARA-C) is an antimetabolite chemotherapy medication used to treat acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), meningeal leukemia, and other cancers. It is a pyrimidine analog that works by interfering with the production of DNA in cancer cells. Cytarabine is typically given as an injection into a vein or into the cerebrospinal fluid.

Product Details

CAS	147-94-4
Molecular Formula	C9H13N3O5
Molecular Weight	243.22
Uses	For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
Mechanism Of Action	Cytarabine acts through direct DNA damage and incorporation into DNA. Cytarabine is cytotoxic to a wide variety of proliferating mammalian cells in culture. It exhibits cell phase specificity, primarily killing cells undergoing DNA synthesis (S-phase) and under certain conditions blocking the progression of cells from the G1 phase to the S-phase. Although the mechanism of action is not completely understood, it appears that cytarabine acts through the inhibition of DNA polymerase. A limited, but significant, incorporation of cytarabine into both DNA and RNA has also been reported.

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